龔靜 博士、教授、博士生導師
研究方向
1. 遺傳變異的功能預測和實驗驗證。系統分析了人類中遺傳變異對miRNA、lncRNA、甲基化、基因表達、可變剪切等功能的影響。構建了一系列遺傳變異相關的數據庫（miRNASNP、lncRNASNP、PancanQTL、Pancan-meQTL、SplicingQTL）。并結合分子流行病學、分子生物學等技術鑒定及驗證了多個癌症相關的易感位點及基因。
2. 生物大數據的整合分析及挖掘。高通量測序數據分析及TCGA、ENCODE、GTEx等大型數據庫資源的整合分析。
教育經曆
2003.09-2008.06 華中科技大學，預防醫學系，醫學學士
2008.09-2013.06 華中科技大學，生物信息學系，工學博士
科研與學術工作經曆
2013.07-2015.06 華中科技大學，公共衛生學院，博士後
2015.07-2017.12 華中科技大學，公共衛生學院，講師
2018.01-2018.09 華中科技大學，公共衛生學院，副教授，碩士生導師
2016.04-2018.04 美國，德克薩斯大學休斯頓健康科學中心(UThealth)，訪問學者
2018.09-至今 77779193永利官网，信息學院/77779193永利官网，教授，博士生導師
科研成果
主要緻力于生物大數據的整合分析和腫瘤相關的分子流行病學研究。主持國家自然科學青年基金、中國博士後基金等課題。以第一作者或通訊作者在Annals of oncology、Nucleic Acids Research（4篇）、Cell Reports、Carcinogenesis、European journal of cancer等雜志上發表SCI文章20多篇，累計影響因子超過100分，其中2篇論文被評為ESI高被引論文，1篇引用次數達250次。
代表性論文：
1.Gong, J.*, Wan, H., Mei, S., Ruan, H., Zhang, Z., Liu, C., Guo, A.Y., Diao, L., Miao, X. and Han, L. (2018) Pancan-meQTL: a database to systematically evaluate the effects of genetic variants on methylation in human cancer. Nucleic Acids Res. (IF:10.2)
2.Gong, J.,Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J., Miao, X. (2018) A polymorphic MYC response element in KBTBD11 influences colorectal cancer risk, especially in interaction with a MYC regulated SNP rs6983267. Annals of oncology. 29(3), 632-639. (IF: 11.8)
3.Gong, J., Li, Y., Liu, C.J., Xiang, Y., Li, C., Ye, Y., Zhang, Z., Hawke, D.H., Park, P.K., Diao, L., Putkey, J.A., Yang, L., Guo, A.Y., Lin, C. and Han, L. (2017) A Pan-cancer Analysis of the Expression and Clinical Relevance of Small Nucleolar RNAs in Human Cancer. Cell reports, 21, 1968-1981.(IF: 8.3,2017.11.14 Volume 21, Issue 7,封面文章)
4.Gong, J.,Mei, S., Liu, C., Xiang, Y., Ye, Y., Zhang, Z., Feng, J., Liu, R., Diao, L., Guo, A.Y., Miao, X., and Han, L. (2018) PancanQTL: systematic identification of cis-eQTLs and trans-eQTLs in 33 cancer types, Nucleic Acids Research.46, D971-D976. (IF:10.2)
5.Gong, J.,Liu, C., Liu, W., Xiang, Y., Diao, L., Guo, A.Y. and Han, L. (2017) LNCediting: a database for functional effects of RNA editing in lncRNAs. Nucleic acids research, 45, D79-D84. (IF:10.2)
6.Gong, J.,Liu, W., Zhang, J., Miao, X. and Guo, A.Y. (2015) lncRNASNP: a database of SNPs in lncRNAs and their potential functions in human and mouse. Nucleic acids research, 43, D181-186. (IF:10.2,引用70次，ESI高被引論文)
7.Gong, J., Tong, Y., Zhang, H.M., Wang, K., Hu, T., Shan, G., Sun, J. and Guo, A.Y. (2012) Genome-wide identification of SNPs in microRNA genes and the SNP effects on microRNA target binding and biogenesis. Human mutation, 33, 254-263. (IF:4.6,引用255次)
8.Zou, D., Lou, J., Ke, J., Mei, S., Li, J., Gong, Y., Yang, Y., Zhong, R., Chang, J.,Gong, J.,* and Miao, X.* (2018) Integrative eQTL-based analysis of colorectal cancer identified a functional polymorphism regulating SLC22A5 expression. European journal of cancer. 93, 1-9. (IF:6.0)
9.Ke, J., Tian, J., Li, J., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. andGong, J*.(2017) Identification of a functional polymorphism affecting microRNA binding in the susceptibility locus 1q25.3 for colorectal cancer. Molecular carcinogenesis, 56, 2014-2021.(IF:4.2)
10.Gong, J.,Tian, J., Lou, J., Ke, J., Li, L., Li, J., Yang, Y., Gong, Y., Zhu, Y., Zhang, Y., Zhong, R., Chang, J. and Miao, X. (2016) A functional polymorphism in lnc-LAMC2-1:1 confers risk of colorectal cancer by affecting miRNA binding. Carcinogenesis, 37, 443-451. (IF:5.1,ESI高被引論文)
11.Ke, J., Lou, J., Zhong, R., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Chang, J. andGong, J.*(2016) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to 3p21.31 in Chinese Population. Scientific reports, 6, 25194.(IF:4.3)
12.Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y., Tian, J., Chang, J., Zhong, R.,Gong, J.*and Miao, X.* (2016) Identification of a functional variant for colorectal cancer risk mapping to chromosome 5q31.1. Oncotarget, 7, 35199-35207.(IF:5.2)
13.Ke, J., Lou, J., Chen, X., Li, J., Liu, C., Gong, Y., Yang, Y., Zhu, Y., Zhang, Y. andGong, J.*(2015) Identification of a Potential Regulatory Variant for Colorectal Cancer Risk Mapping to Chromosome 5q31.1: A Post-GWAS Study. PloS one, 10, e0138478.(IF:2.8)
14.Gong, J.,Liu, C., Liu, W., Wu, Y., Ma, Z., Chen, H. and Guo, A.Y. (2015) An update of miRNASNP database for better SNP selection by GWAS data, miRNA expression and online tools. Database : the journal of biological databases and curation, 2015, bav029.(IF:3.3)
15.Xia, X., Chen, W., Li, J., Chen, X., Rui, R., Liu, C., Sun, Y., Liu, L.,Gong, J.*and Yuan, P*. (2014) Body mass index and risk of breast cancer: a nonlinear dose-response meta-analysis of prospective studies. Scientific reports, 4, 7480.(IF:4.3)
16.Gong, J.,Wu, Y., Zhang, X., Liao, Y., Sibanda, V.L., Liu, W. and Guo, A.Y. (2014) Comprehensive analysis of human small RNA sequencing data provides insights into expression profiles and miRNA editing. RNA biology, 11, 1375-1385.(IF:3.9)
17.Gong, J., Shen, N., Zhang, H.M., Zhong, R., Chen, W., Miao, X., and Guo, A.Y. (2014). A genetic variant in microRNA target site of TGF-beta signaling pathway increases the risk of colorectal cancer in a Chinese population. Tumour biology, 35, 4301-4306. (IF:3.7)
18.Hong, Y., Chen, X.Q., Li, J.Y., Liu, C., Shen, N., Zhu, B.B.,Gong, J.,* and Chen, W.* (2014). Current evidence on the association between rs3757318 of C6orf97 and breast cancer risk: a meta-analysis. Asian Pacific journal of cancer prevention : APJCP 15, 8051-8055.
19.Liu, D.＃,Gong, J.#, Dai, W., Kang, X., Huang, Z., Zhang, H.M., Liu, W., Liu, L., Ma, J., Xia, Z., Chen, Y., Chen, Y., Wang, D., Ni, P., Guo, A.Y. and Xiong, X. (2012) The genome of Ganoderma lucidum provides insights into triterpenes biosynthesis and wood degradation. PloS one, 7, e36146. (IF:2.8)
20.龔靜,柳純潔,缪小平,郭安源.人類長鍊非編碼RNA相關SNP鑒定與功能預測的研究進展[J].生物技術通報,2015,11:1-8.
