專任教師

張強

訪問次數:發布日期:2020-09-27

張強 博士、副教授、士生導師

中共黨員,農業微生物資源發掘與利用全國重點實驗室固定人員,湖北江夏實驗室兼職研究員。聚焦動物流感、豬鍊球菌等重要人獸共患病以及非洲豬瘟等重大動物傳染病,結合腸道微生物學、納米生物學、藥物化學等多個領域,長期緻力于新型疫病防控技術的理論與應用研究。以第一或通訊作者(含共同)在Genome BiologyACS NanoAdvanced ScienceGut Microbes等期刊共發表SCI論文20餘篇,其中,中科院SCI分區111篇,入選微生物學領域高被引論文1篇;授權國家發明專利9件,國際發明專利2件;參與編寫著作3部;主持國家自然科學基金項目2項、湖北省傑青項目1項、博士後科學基金1項,參與國家及省部級項目8項;獲得湖北省科技成果推廣一等獎1項(排名7/20)。擔任Frontiers in Immunology客座副主編,npj VaccinesInfection, Genetics and Evolution等雜志審稿人


教育經曆

2005.9-2009.6 山東農業大學,動物醫學,學士

2009.9-2015.6 77779193永利官网,預防獸醫學,博士,導師:金梅林教授


工作經曆

2015.7-2020.9 77779193永利官网,生命科學技術學院,博士後,合作導師:金梅林教授/張忠明教授

2020.9至今 77779193永利官网,動物科學技術學院、動物醫學院/77779193永利官网,副教授


研究方向

1) 重要人獸共患病和重大動物傳染病感染與抗感染機制研究

2) 新型檢測技術和防控制劑開發


代表論文

1) Zhang Q, Hu J, Feng J, Hu X, Wang T, Gong W, Huang K, Guo Y, Zou Z, Lin X, Zhou R, Yuan Y, Zhang A, Wei H, Cao G, Liu C*, Chen L*, Jin M*, Influenza infection elicits an expansion of gut population of endogenous Bifidobacterium animalis which protects mice against infection. Genome Biol. 2020, 21(1):99. (獨立一作,IF: 12.3)

2) Hu X, Sun X, Zhao Y, Iv C, Sun X, Jin M*, Zhang Q*. GlcNac produced by the gut microbiome enhances host influenza resistance by modulating NK cells. Gut Microbes. 2023 Dec;15(2):2271620. (主通訊,IF: 12.2)

3) Liu X, Yang C, Lin X, Sun X, Chen H, Zhang Q*, Jin M*. Phosphorylation of S-S-S Motif in Nuclear Export Protein (NEP) Plays a Critical Role in Viral Ribonucleoprotein (vRNP) Nuclear Export of Influenza A and B Viruses. Advanced Science. 2025;12(2):e2309477. (共同通訊,IF: 14.3)

4) Li B#, Zhao Y#, Wu X, Wu H, Tang W, Yu X, Mou J, Tan W, Jin M*, Li W*, Zhang Q*, and Liu M*. Abiotic Synthetic Antibody Inhibitor with Broad-Spectrum Neutralization and Antiviral Efficacy against Escaping SARS-CoV2 Variants. ACS Nano. 2023;17(7):7017-7034. (共同通訊,IF: 17.1)

5) Li R#., Zhao Y#, Fan H, Zhou H., Yin S, Zhang Q*, Jin M*, Liu G*, Huang L*, Metasurface-Driven and Nanomaterial-Coupled Plasmonic Biosensor for the Rapid and Quantitative Clinical Identification of Neutralizing Antibodies against SARS-CoV-2 Variants. Adv. Funct. Mater. 2023, 2306145. (共同通訊,IF: 19.0)

6) Zhang Q#, Zhang H#, Gao J#, Huang K, Yang Y, Hui X, He X, Li C, Gong W, Zhang Y, Zhao Y, Peng C, Gao X, Chen H, Zou Z*, Shi Z*, Jin M*. A serological survey of SARS-CoV-2 in cat in Wuhan. Emerg Microbes Infect. 2020, 9(1):2013-2019. (共一排一,IF: 13.2,高被引)

7) Li R#, Zhao Y#, Fan H#, Chen M, Hu W, Zhang Q*, Jin M*, Liu GL*, Huang L*. Versatile nanorobot hand biosensor for specific capture and ultrasensitive quantification of viral nanoparticles. Mater Today Bio. 2022;16:100444. (共同通訊,IF: 8.2)

8) Zhong ZJ, Hu XT, Cheng LP*, Zhang XY, Zhang Q*, Zhang J. Discovery of novel thiophene derivatives as potent neuraminidase inhibitors. Eur J Med Chem. 2021, 225:113762. (共同通訊,IF: 6.514)

9) Zhao Y#, Li R#, Lv C, Zhang Y, Zhou H, Xia X, Yu S, Wang Y, Huang L*, Zhang Q*, Liu GL*, Jin M*. One-Step Rapid and Sensitive ASFV p30 Antibody Detection via Nanoplasmonic Biosensors. Microbiol Spectr. 2022: e0234322. (共同通訊,IF:3.7)

10) Hu X, Zhao Y, Yang Y, Gong W, Sun X, Yang L, Zhang Q*, Jin M*. Akkermansia muciniphila Improves Host Defense Against Influenza Virus Infection. Front Microbiol. 2021, 11:586476. (共同通訊,IF:5.64)

11) Zhao Y#, Yang Y#, Gao J, Huang K, Hu C, Hui X, He X, Li C, Gong W, Lv C, Zhang Y, Chen H, Zou Z, Zhang Q*, Jin M*. A serological survey of severe acute respiratory syndrome coronavirus 2 in wuhan. Transbound Emerg Dis. 2021. doi: 10.1111/tbed.14024. (共同通訊,IF:5.005)

12) Hui X, Xu Z, Cao L, Liu L, Lin X, Yang Y, Sun X, Zhang Q*, Jin M*. HP0487 contributes to the virulence of Streptococcus suis serotype 2 by mediating bacterial adhesion and anti-phagocytosis to neutrophils. Vet Microbiol. 2021, 260:109164. (共同通訊,IF:3.293)

13) Wu C, Lv C, Zhao Y, Zhu W, Liu L, Wang T, Kang C, Yang Y, Sun X, Zhang Q*, Jin M*. Characterization of Erysipelothrix rhusiopathiae Isolates from Diseased Pigs in 15 Chinese Provinces from 2012 to 2018. Microorganisms. 2021; 9(12):2615. (共同通訊,IF: 4.128)

14) Yang H#, Huang J#, Hu X, Hu M, Zhang Q*, Jin M*. Comparative Genome Analysis of Streptococcus suis Serotype 9 Isolates from China, The Netherland, and the U.K. Life. 2021; 11(12):1324. (共同通訊,IF: 3.817)

15) Lv C#, Zhao Y#, Jiang L, Zhao L, Wu C, Hui X, Hu X, Shao Z, Xia X, Sun X, Zhang Q*, Jin M*. Development of a Dual ELISA for the Detection of CD2v-Unexpressed Lower-Virulence Mutational ASFV. Life. 2021; 11(11):1214. (共同通訊,IF: 3.817)

16) Yang Y, Lv C, Fan J, Zhao Y, Jiang L, Sun X, Zhang Q*, Jin M*. Development of a chemiluminescence immunoassay to accurately detect African swine fever virus antibodies in serum. J Virol Methods. 2021, 298:114269. (共同通訊,IF:2.014)

17) Zhang Q#,  Huang J#, Yu J,  Xu Z,  Liu L, Song Y, Sun X, Zhang A* and Jin M*, HP1330 Contributes to Streptococcus suis Virulence by Inducing TLR2- and ERK1/2-Dependent Pro-inammatory Responses and Influencing In Vivo S. suis Loads, Front Immunol. 2017, 8:869. (共一排一,IF:7.561)

18) Huang K#, Zhang Q#, Song Y, Zhang Z, Zhang A, Xiao J, Jin M*, Characterization of Spectinomycin Resistancein Streptococcus suis Leads to Two Novel Insights into Drug Resistance Formation and Dissemination Mechanism, Antimicrob Agents Chemother. 2016, 7.25, (60): 6390~6392. (共同一作,IF:5.191)

19) Zhang Q#, Yang Y#, Yan S, Liu J, Xu Z, Yu J, Song Y, Zhang A, Jin M*, A novel pro-inflammatory protein of Streptococcus suis 2 induces the Toll-like receptor 2-dependent expression of pro-inflammatory cytokines in RAW 264.7 macrophages via activation of ERK1/2 pathway, Front Microbiol. 2015, 6: 178. (共一排一,IF:5.64)

20) Zhang Q, Liu J, Yan S, Yang Y, Zhang A, Jin M*. Fluoroquinolone-resistant Haemophilus parasuis isolates exhibit more putative virulence factors than their susceptible counterparts. J Clin Microbiol. 2013, 51(9):3130-1. (獨立一作,IF:5.948)

21) Zhang Q, Zhou M, Song D, Zhao J, Zhang A, Jin M*. Molecular characterisation of resistance to fluoroquinolones in Haemophilus parasuis isolated from China. Int J Antimicrob Agents. 2013 Jul;42(1):87-9. (獨立一作,IF:5.283)

22) Zhou M#, Zhang Q#, Zhao J, Jin M*. Haemophilus parasuis encodes two functional cytolethal distending toxins: CdtC contains an atypical cholesterol recognition/interaction region. PLoS One. 2012,7(3):e32580. (共同一作,IF:3.24)


授權專利

1) Meilin Jin; Qiang Zhang; Xiaotong Hu; Li Yang; Ting Wang; Xiaomei Sun; Chao Kang; Ming ZhongApplication of valine in preparing medicine for treating or preventing avian influenza virus infection, 2023-08-08國際發明專利(美國), 申請号:US202117146413, 專利号:US11717503B2

2) Meilin Jin; Qiang Zhang; Xiaotong Hu; Li Yang; Jin Hu; Ting Wang; Xiaomei Sun; Zhong Zou; Wenxiao Gong; Xian Lin. Bifidobacterium animalis and application of compound bacterium preparation prepared from bifidobacterium animalis in preparing medicine for treating or preventing avian influenza virus infection, 2023-10-17, 國際發明專利(美國), 申請号:US202117141104,專利号:US 11786566B2

3) 金梅林,張強,胡曉通,楊麗,王婷,孫小美,康超,鐘鳴,缬氨酸在制備治療或預防禽流感病毒感染的藥物中的應用,2020-12-22,中國,ZL202010048679.7

4) 金梅林,張強,胡曉通,楊麗,胡進,王婷,孫小美,鄒忠,龔文孝,林顯,動物雙歧杆菌及其制備的複合菌制劑在制備治療或預防禽流感病毒感染的藥物中的應用2020-12-01,中國,ZL202010031196.6

5) 金梅林胡曉通張強楊麗王婷孫小美康超鐘鳴,嗜黏蛋白阿克曼氏菌在制備治療或預防禽流感病毒感染的微生态制劑中的應用,2021-05-14, 中國, ZL202010047686.5

6) 金梅林,楊永,張強,趙亞,孫小美,呂長傑,楊麗,一種非洲豬瘟病毒截短蛋白及其在制備ELISA檢測試劑盒中的應用2021-06-29中國,ZL202010700335.X

7) 金梅林,楊永,張強,趙亞,孫小美,呂長傑,楊麗,一種非洲豬瘟病毒截短蛋白p54制備的單克隆抗體及其應用,2021-08-03,中國,ZL202010698954.X

8) 劉名茗李冰雪趙亞張強李炜,一種抗SARS-CoV-2病毒的人工模拟抗體及其應用,2023-04-07中國,ZL202210939738.9

9) 金梅林,趙建平,周明光,宋岱松,張強,張安定,石建,康超,徐高原,陳煥春,表達副豬嗜血杆菌表面抗原的豬霍亂沙門氏菌減毒疫苗2015.10.28,中國,ZL201310039113.8

10) 金梅林,趙建平,周明光,宋岱松,張強,張安定,石建,康超,徐高原,陳煥春,一種副豬嗜血杆菌減毒沙門氏菌苗,2015.10.28,中國,ZL201310039080.7

11) 金梅林,趙建平,周明光,宋岱松,張強,張安定,石建,康超,徐高原,陳煥春,一種副豬嗜血杆菌-豬霍亂沙門氏菌二聯基因工程苗,2015.10.28,中國,ZL201310040712.1


基金項目

1) 國家自然科學基金面上項目32172891流感病毒感染誘導腸道代謝分子GlcNAc合成及其抗流感作用機制的研究2022/01-2025/1258萬元,在研,主持

2) 國家自然科學基金青年科學基金項目31702253豬鍊球菌表面蛋白ZnMc誘導過度炎症反應的分子機制研究2018/1-2020/1226萬元,已結題,主持

3) 中國博士後科學基金面上項目一等資助 2015M580654豬鍊球菌2型抑炎蛋白HP1914作用機制的研究2015/11-2017/11,8萬元,已結題,主持

4) 國家重點研發計劃2016YFD0500801,家禽重大疫病診斷新技術研究,2016/7-2020/12693萬元(本人可支配金額70萬元已結題,骨幹

5) 湖北省重點研發計劃2021ACB004,變異新冠病毒預警及風險評估體系建設,2021/01-2021/12400萬元(本人可支配金額20萬元),在研,骨幹

6) 國家重點研發計劃2020YFC0845800,新型冠狀病毒感染不同進程與宿主的相互作用研究,400萬元本人可支配金額20萬元),2020/3-2021/6, 已結題骨幹

7) 湖北省重大專項2020ABA016,主要動植物品種選育及生物制品研發, 2020/11-2023/12,630萬元(本人可支配金額20萬元),在研,骨幹

8) 湖北省技術創新專項重大項目2019ABA089,非洲豬瘟防控關鍵技術研究與示範,500萬元本人可支配金額10萬元),2019/1-2021/12已結題骨幹

9) 武漢市科技重大專項2023020302020573,非洲豬瘟新型疫苗創制,2000萬(本人可支配金額48萬元),2023/6-2026/6,在研,骨幹

10) 新進教師科研啟動專項2662021SYQD002,流感病毒感染誘導腸道代謝分子GlcNAc的合成及其抗流感作用機制的研究2021/01-2023/1220,在研,主持


獲得獎項

1) 金梅林,康超,譚臣,湯細彪,張安定,王湘如,張強,徐高原,吳斌,張錦軍,周明光,陳關平,魏燕鳴,鐘鳴,貝為成,錢平,陳幕琳,孫小美,陳波,尹争豔。豬鍊球菌病高效安全防控技術集成與推廣應用,湖北省成果推廣獎一等獎2018.12

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