李瓅(Li Li，PhD, Professor)博士、教授、博士生導師
Education (教育經曆)：
2008-2015, Ph.D. (醫學博士), Princess Margaret Cancer Centre, and Department of Medical Biophysics, Faculty of Medicine, University of Toronto (2020泰晤士高等教育世界大學排名#18).
2004-2008, Honours Bachelor of Science Degree (本科，榮譽理科學士), Immunology Specialist Program, Department of Immunology, Faculty of Medicine, University of Toronto.
2000-2004, Ontario Secondary School Diploma, Ontario Scholar, Canadian International School (Singapore).
Professional Experiences (科研工作經曆)：
2021-present，Professor, College of Biomedicine and Health & College of Life Science and Technology, Huazhong Agricultural University (77779193永利官网,77779193永利官网&生命科學技術學院，教授).
2019-2020，Research Fellow, Arthur and Sonia Labatt Brain Tumor Research Centre, The Hospital for Sick Children, University of Toronto (加拿大多倫多大學兒童醫院腦腫瘤研究中心研究員).
2015-2018，Postdoctoral Fellow, Structural Genomics Consortium and University of Toronto（加拿大多倫多大學結構基因組學研究所博士後）.
Research Interests (研究方向)：
通過跨學科的多種實驗策略研究癌症起源與緻癌機理，免疫學,遺傳學，DNA損傷修複landscape，免疫治療及新型抗癌療法，蛋白質學以及有關對人類生理與疾病具有重要作用的生物分子非共價相互作用的機理等。
Selected Publications（代表論文）:
1.Zhang H #, Dong C#,Li L#, Wasney GA, Min J.Structural insights into the modulatory role of the accessory protein WYL1 in the Type VI-D CRISPR-Cas system.Nucleic Acids Research, 2019,47: 5420–5428. (#co-first author, equal contributions)
2.Li L#, Guturi KKN#, Gautreau B, Patel PS, Saad A, Morii M, Mateo F, Palomero L, Barbour H, Gomez A, Ng D, Kotlyar M, Pastrello C, Jackson HW, Khokha R, Jurisica I, Affar EB, Raught B, Sanchez O, Alaoui-Jamali M, Pujana MA, Hakem A, Hakem R.Ubiquitin ligase RNF8 suppresses Notch signaling to regulate mammary development and tumorigenesis.Journal of Clinical Investigation, 2018, 128: 4525–4542. (#equal contributions)
3.Dong C#, Zhang H#,Li L#, Tempel W, Loppnau P, Min J.Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.Nature Chemical Biology(2018)14: 466–473.(#co-first author, equal contributions)
4.Ghamrasni SE, Cardoso R,Li L, Guturi KKN, Bjerregaard VA, Liu Y, Venkatesan S, Hande MP, Henderson JT, Sanchez O, Hickson ID, Hakem A, Hakem R.Rad54 and Mus81 cooperation promotes DNA damage repair and restrains chromosome missegregation.Oncogene, 2016,35: 4836–4845.
5.Halaby M, Hakem A,Li L, Ghamrasni SE, Venkatesan S, Hande MP, Sanchez O, Hakem R.Synergistic interaction of Rnf8 and p53 in the protection against genomic instability and tumorigenesis.PLoS Genetics, 2013, 9(1):e1003259.
6.Li L, Halaby M, Hakem A, Cardoso R, Ghamrasni SE, Harding S, Chan N, Bristow R, Sanchez O, Durocher D, Hakem R.Rnf8 deficiency impairs class switch recombination, spermatogenesis, and genomic integrity and predisposes for cancer.Journal of Experimental Medicine, 2010, 207: 983–997.
Funding & Awards（主持的資助與獎項）:
1.國家自然科學基金面上項目2022，中國。
2.湖北省高層次人才項目2021,中國。
3.77779193永利官网高層次人才啟動經費2021，中國。
4.Restracomp Fellowship 2019-2020, Canada.
5.University of Toronto Doctoral Completion Award 2013-2014, Canada.
6.2 MBP UTF Excellence Awards 2011-2013, Canada.
7.Keystone Symposium Scholarship 2011, the USA.
8.Ontario Graduate Scholarship 2011-2012, Canada.
9.Chinese Government Award for Outstanding Self-financed Students Abroad 2010 (中國“國家優秀自費留學生獎學金”, i.e.非公派), China.
10.Full Scholarship for PhD program in Biomedical Sciences at the Albert Einstein College of Medicine, 2008, New York, the USA. (Declined; 2007 GRE scores above 90 percentiles).
11.2 Shou-Yun Pang Scholarships 2006-2008, the University of Toronto, Canada.
12.New College Student Council In-Course OSOTF Scholarship 2005-2006, the University of Toronto, Canada.
13.Canadian Open Mathematics Challenge Honour Roll (international student category), 2002，the Canadian Mathematical Society, Canada.
Teaching Courses（講授課程）:
Immunology (免疫學理論課程,全英文教學)
Experimental Immunology (免疫學實驗課程,中英文雙語教學)
Other Academic Appointments & Activities (學術兼職等其它活動):
湖北省細胞生物學學會第四屆理事會理事
湖北省細胞生物學學會青工委副主任
77779193永利官网研究生公共英語教學咨詢委員會委員
77779193永利官网邁維代謝校企研究生聯合培養基地負責人
Research Opportunities (實驗室人員招聘信息)：
The lab currently has opportunities opening for Master’s students in both academic and professional streams, PhD students, postdoctoral fellows, bioinformaticians，technicians and research assistants. All interested people are encouraged to contact the lab head by email with a detailed Curriculum Vitae/Resume, plus any other related materials (Any relevant skill including programming or academic qualification is an asset, and please provide a brief description).本實驗室現招募學術型和專業型碩士研究生、博士生、博士後、科研助理及volunteer實習生等科研人員。本實驗室對學生采取小而精的雙語或全英語培養模式，鼓勵學生pursue academic excellence,開展自己感興趣的科學研究成長為independent scientists。
研究生招生方向：
學術型：癌症遺傳學&免疫遺傳學。專業型：生物與醫藥。
博士後招聘：
根據積累的科研經驗，提供具有國際競争力的職業發展機會和充足的年薪制及學校各種福利待遇加科研成果績效，請先Email CV/簡曆,然後具體online or onsite面議。Postdoctoral Fellow Position Opportunities are currently available and open to all interested candidates on the planet of the Earth. The lab offers internationally competitive postdoctoral research training opportunities and salaries equivalent to top universities across the globe, and international candidates are warmly welcome to apply, if you have a genuine strong curiosity/interest for science and are highly self-motivated to develop a professional career in biomedical research, please contact the Principle Investigator of the Li瓅Lab, Dr. Johnny Li Li, directly via Email (johnnyinphoton@hotmail.com)first with a CV/Resume outlining all relevant academic qualifications and research experiences, and then we will chat in details online or onsite.
本招聘長期有效。歡迎大家聯系我(Email:lili.johnny@mail.hzau.edu.cn)，加盟實驗室或合作研究，共同發展科研事業,探索宇宙奧秘！
